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Topics:
Hematologic Malignancies • Medical Oncology • Myeloma • Internal Medicine • Hematology • Neuropathy • Neurology
Do you recommend work up for POEMS and/or amyloidosis for IgM monoclonal gammopathies associated with neuropathy?
Can you expand on this by sharing exactly what this routine workup should include? What additional tests outside of evaluating for POEMS and amyloidosis do you recommend?
Answer from: Medical Oncologist at Academic Institution
While IgM monoclonal disorders, amyloidosis, and POEMS syndrome may all be associated with peripheral neuropathy, they are not often confused with one another. A patient with a peripheral neuropathy can be diagnosed most simply by a serum protein electrophoresis. The presence of a monoclonal IgM spi...
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Answer from: Medical Oncologist at Academic Institution
If you have identified somebody with neuropathy and a monoclonal IgM protein, there are a few things you can/should do to get to the underlying diagnosis. The question is whether these are true, true, and unrelated or in fact, part of the same disease process.
1) EMG/NCS - presumably this has...