Do you routinely offer doxycycline or minocycline prophylaxis for cutaneous reactions to EGFR inhibitors such as cetuximab?  

When we use EGFR inhibitor for colorectal cancer, we routinely use the STEPP regimen that showed significant benefits in the phase II study including skin moisturizers, sunscreen, topic steroids, and doxycycline. In the phase II STEPP study, using this pre-emptive treatment significantly decreased s...