Do you regularly incorporate oral cryotherapy in your practice for patients receiving oxaliplatin to decrease the risk of thermal hyperalgesia?

I personally am not opposed if a patient wishes to try it but I also am not a big believer. There are several issues here - the peripheral neuropathy will continue to be an issue overall, this study regressed to the mean over time and it’s a smaller study (although randomized which is very helpful)....

We have tried this with mixed results as some patients develop a paradoxical hypersensitivity to the oral cryotherapy approach. We also consistently use peripheral cryotherapy 15 minutes prior, during infusion, and 15 minutes after using one of the many commercially available cryotherapy glove and s...