Can defibrotide be given safely for VOD in patients with refractory thrombocytopenia to platelet transfusions?  

The short answer is "yes."The slightly longer answer is: “Yes, and in patients with veno-occlusive disease (VOD), the use of defibrotide is potentially life-saving (Richardson et al., PMID 26825712).” In the cited study, which led to its FDA approval for this indication, there was no sig...