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Topics:
Radiation Oncology • Neuro-Oncology
Do you routinely use hippocampal sparing techniques in the treatment of primary brain tumors?
If so, do you have specific dose constraints you find reasonably achievable given the difficulties in achieving some of the very low dose goals noted in the available literature?
Answer from: Radiation Oncologist at Community Practice
The hypothesis of the hippocampus as an organ at risk centers on the exquisite radiosensitivity of neuro-regnerative stem cells located within the hippocampal dentate gyrus and important for memory formation.
Pending results from NRG CC001, a recently completed phase III trial of whole-brain...
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Answer from: Radiation Oncologist at Academic Institution
Yes, indeed we do. We routinely contour both hippocampus, using the RTOG atlas in all patients, even in those in whom we know that we will not be able to achieve sparing, primarily, to develop a robust dose-response data base. As to dosimetric constraints, there are a number of approaches; the sim...