Do you see a current or future clinical role of neurofilament light chain in the diagnosis or workup of multiple sclerosis?  

I see the neurofilament light chain as a helpful tool for future MS monitoring. I don't believe it has a role in the initial diagnosis, as CNS damage generally causes elevations. However, research is exploring its prognostic potential for aggressive or highly active disease during the initial work-u...

Recent publications have offered age-related normative data for serum neurofilament light chain (sNfL) (Khalil et al., PMID 32041951 and Beltran, PMID 38179631). Previous research has suggested that elevated z-scores for sNfL, normalized to healthy controls, may predict disability. Moreove...