Please select the option that best describes you:
Do you send CSF or serum ACE levels in the workup of neurosarcoidosis?
If not, are there any serum or CSF tests you consider to be helpful?
Answer from: at Community Practice
Unfortunately, serum and/or CSF ACE levels are just not sensitive or specific enough to guide the diagnosis or treatment of sarcoidosis, particularly neurosarcoid. Rather, imaging characteristics, specific organ system involvement, and biopsy results are much more useful in my practice.Bradshaw et a...
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Answer from: at Community Practice
If you are working up for neurosarcoidosis, then ACE levels are included.
Answer from: at Community Practice
I agree with Dr. @Elsbernd.
Also worth mentioning a paper from 2019 which suggested improved sensitivity and specificity of sIL-2R (soluble interleukin-2 receptor) compared to ACE as an alternative biomarker for the diagnosis of sarcoidosis (Eurelings et al, PMID 31622413). Additionally, a 2020 stu...