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Topics:
Pediatric Hematology/Oncology • Bone Marrow Transplant • Pediatric Hematology • Drug Toxicity • Pediatric Oncology
Do you use prophylactic defibrotide in pediatric patients undergoing BMT who are considered to be at high risk for the development of VOD/SOS?
What features make a patient high-risk?
Answer from: at Academic Institution
Yes, I routinely use prophylactic defibrotide for pediatric patients with high-risk features based on the results of the pediatric trial in Europe, meta-analysis and institutional experience. Perhaps the clearest indications are children with osteopetrosis, HLH, and MPS disorders as they have very h...
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Answer from: at Community Practice
Prophylactic defibrotide can indeed be used in pediatric patients undergoing bone marrow transplant (BMT) who are considered to be at high risk for the development of veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS).Studies, including those leading to defibrotide’s FDA approval...