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Topics:
Hematologic Malignancies • Medical Oncology • Myelodysplastic Syndromes • Internal Medicine • Hematology
Does isolated del(5q) have the same prognostic implications for post-PV secondary myelofibrosis as it does in MDS?
Given the rarity of this in MF, is it still predictive of response to lenalidomide therapy?
Answer from: Medical Oncologist at Academic Institution
Karyotypic abnormalities are rare in PV and ET. Abnormalities in myelofibrosis (MF) that are associated with an inferior prognosis are: 20q-, 13q-, +9, chromosome 1 translocation/duplication, -Y or sex chromosome abnormality other than –Y. There are few reports of del5q in MPN in general and n...
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