Does liver-directed therapy (SBRT, Y-90, TACE, RFA, microwave ablation, etc.) improve overall survival?  

This is a loaded question. The issue is that many of the studies detailing the use of TACE, RFA, and MWA do not collect QOL data. Survival is also not collected due to lack of long term follow up. SBRT data is mostly in the retrospective setting although there is some QOL data in Phase II prospectiv...