Does papillary thyroid cancer with extensive squamous differentiation require specialized treatment beyond RAI and TSH suppression?

Patient has 1.1 cm follicular variant PTC with extensive squamous differentiation. Neg 2/2 nodes. Already had total thyroidectomy. Would you recommend RAI or more tx like chemo due to squamous component?

Answer from: Medical Oncologist at Community Practice

Squamous differentiation associated with PTC represents an aggressive pathologic feature with poor long-term outcomes. I would consider this as a step towards dedifferentiation. This disease is not chemo sensitive unfortunately. Chemo can be considered for advanced disease that requires rapid treatm...

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at Loma Vista Endocrinology Inc
Thank you Dr. @Seetharamu, that was very helpful.

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Does papillary thyroid cancer with extensive squamous differentiation require specialized treatment beyond RAI and TSH suppression?

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