For locally recurrent disease after surgical resection of EGFR/ALK positive NSCLC that appears suitable for chemoradiation, would you proceed directly to chemoradiation or consider TKI first?  

It depends on a lot of factors—initial stage, whether adjuvant chemo was administered or not, how soon after completion of initial treatment did patient recur, was a complete restaging work up done? How bulky is the recurrence? If patients have limited loco-regional recurrence and did not rec...