For patients between 40-49 years old who undergo lumpectomy, how do you choose between offering PBI per the updated PBI guidelines or boosting based on boost guidelines?   

I think this is an informed discussion that includes data on the pros/cons of each approach. One challenge is that when patients hear about a 5 fx PBI approach, it's harder to rationalize 15 fx WBI (I use SIB for my boosts). You can consider PBI for low-risk patients in this age group but I also co...

Based on pathology, if favorable then favor PBI with 30 on 5 (boost is built in). If aggressive phenotype/triple-negative favor whole breast hypo with boost (26 in 5 with boost or 40 in with 48 Gy SIB boost)