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Topics:
Gastrointestinal Cancers • Medical Oncology • Liver and Pancreas Tumors • Internal Medicine • Hepatocellular Carcinoma • Gastroenterology • Journal Club ft. NEJM publications • General Hepatology
For patients with HCC receiving atezo/bev, would you advise any other clinical investigations scheduled during treatment other than basic lab monitoring?
i.e. EGD surveillance for varices?
Answer from: Medical Oncologist at Academic Institution
In the IMBrave 150 study, the most common serious toxicity in the AB arm was GI bleeding. And everyone was required to have their varices both evaluated and treated. It’s not convenient, but get the EGD before starting treatment!
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Answer from: Medical Oncologist at Academic Institution
The important pre treatment basic work up, in addition to basic lab monitoring, including labs, urine analysis, TSH, free T4, is to evaluate the clinical need for EGD in patients with cirrhosis and portal HTN as indicated by the study inclusion criteria. Management of varices is up to clinical team ...
Answer from: Medical Oncologist at Academic Institution
I would recommend following thyroid function tests, but no additional monitoring.