What are your first line treatment choices for metastatic combined HCC/Cholangiocarcinoma?  

This diagnosis is mostly reached after a biopsy of an LR-M liver lesion. There are no prospective trials or high-quality data to guide therapy because such patients were excluded from pure BTC or HCC trials. It is reasonable to treat using an HCC or BTC pathway. I would commit to one and proceed wi...

Combined HCC/Cholangiocarcinoma is a rare phenotype and there is a paucity of data on the right treatment. If a biopsy is obtained, I would try to obtain several sites and send for molecular testing to see the different clones/mutation profiles. In clinic, I have tried to combine gemcitabine/cisplat...