Would you ever consider using durvalumab/tremelimumab in second line after progression on atezolizumab and bevacizumab in advanced HCC?
Answer from: Medical Oncologist at Academic Institution
This is a really interesting question as primary prospective trials in this setting are limited. Following progression of atezolizumab/bevacizumab, there was a recent abstract of a phase 2 trial using the combination regorafenib + pembrolizumab (N=95 patients, cohort 1 of 68 patients having received...
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Medical Oncologist at Houston Cancer Treatment and Immunotherapy Center Agree!
Answer from: Medical Oncologist at Community Practice
If not previously used, both Category 1, NCCN accepted first-line HCC regimens: atezolizumab plus bevacizumab and trelimumab plus durvalumab are reasonable to consider for subsequent lines of treatment. However, there is no comparative data to define optimal treatment after first-line systemic thera...
Agree!