For patients with resected colon cancer, to what extent would you adapt adjuvant chemotherapy if ctDNA results don't correspond with your initial treatment recommendation?  

Data in this field is evolving quickly. We will have more answers in the upcoming months as BESPOKE, SU2C MGH, more follow-up on PEGASUS presented at ESMO a few weeks ago, as well as CIRCULATE-JAPAN and CIRCULATE-US accrue and read out.Till that, the strongest evidence would be from what happened to...

Addressing each of the posed scenarios individually: If you had recommended 6 months 5-FU and the initial ctDNA is positive, do you transition to a doublet?There is no data yet to use ctDNA to change your treatment recommendations and would still strongly urge clinical trials. Caution must also b...

This is a complex and evolving space and currently, we do not have sufficient data to provide high-level evidence of treatment decisions with ctDNA. That being said, in addition to what Dr. @Kasi and Dr. @Parikh have noted, a few practical considerations to take into account: If you had recommended...