For patients with scleroderma at high risk of renal crisis, would you feel comfortable giving corticosteroids as pre-medication for rituximab?

I typically will not modify the pre-treatment steroid regimen for Rituxan for scleroderma patients. However, I do assess the patient's risk for scleroderma renal crisis. For example, I consider them high risk if they have early, diffuse scleroderma and particularly if they produce antibodies to RNA ...