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For recurrent glioblastoma treated with combined re-irradiation and bevacizumab, how long do you continue bevacizumab?
Would you continue it until progression of disease? Or would you switch immediately to next line systemic therapy?
Answer from: Medical Oncologist at Academic Institution
In the event of recurrent GBM, for example, if i.e. fSRT regimen like 30 Gy/5fx to be used for salvage, would not exceed more than 12 doses (6 cycles) of bevacizumab max. Even in the pseudo-response setting, the toxicity far outweighs the benefit beyond this.
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