For young adults (20-39 years of age) with moderate hypercholesterolemia, should we aim to reduce LDL-C levels by > or equal to 50% and maintain them on long-term statin therapy?  

Cumulative lifetime exposure to elevated LDL levels is associated with cardiovascular events. That is, even modest elevations of LDL, if present for a long time, can contribute just as much if not more to risk than late-life, elevated LDL. In observational studies, the cumulative lifetime exposure t...