Given the results of LU-002 presented at ASCO 2024, are there situations and/or patient subgroups who still derive benefit from local consolidative therapy for oliogmetastatic NSCLC?
Answer from: Radiation Oncologist at Academic Institution
Certainly was a disappointing result but I still do believe there are subsets that would demonstrate greater benefit of the addition of local therapies as they transition to maintenance IO. I think MRD ctDNA could play a pivotal role in patient selection for these approaches moving forward, and alte...
Answer from: Radiation Oncologist at Community Practice
This is a tricky trial to interpret. They allowed a mixture of "stage I" primaries with oligomets and "stage III" locoregional disease with oligomets. The former got SBRT to the primary and the latter got 45 Gy/15 fx to primary and involved LN. There is a huge difference in the "ablativeness" of tho...
Answer from: Radiation Oncologist at Academic Institution
What role does local therapy play in the setting of disseminated disease? A deceptively simple question, it belies the evolving therapeutic landscape of personalized care. Local control is a worthy goal for unresectable patients for whom progression would lead to problems regardless of systemic dise...
Answer from: Radiation Oncologist at Academic Institution
Decide if local treatment is indicated, that is the first step, followed by the choice of dose and technique, the former dictated by tumor-related factors, namely target volume and location, and the latter by treatment-related factors, namely, available technology and expertise; RTOG 0617 is, perhap...
Comments
Radiation Oncologist at Lake Huron Medical Center What a great answer. Thanks for that
Answer from: Radiation Oncologist at Academic Institution
No! Not outside a clinical trial. I also request that folks discussing this issue avoid vague terms like ablation, ablative dose, and ablative intent that have no biological basis.
Comments
Radiation Oncologist at Radiation Oncology Associates I respectfully disagree. Ablate: "To take away, re...
Radiation Oncologist at Turville Bay MRI & Radiation Oncology Center Based on this, you would presumably favor 74 Gy th...