Has there been an observed interaction between ACE inhibitors and development of angioedema in a block demarcated superficial radiation therapy treatment volume (ex. lip)?

ACE inhibitors are the leading cause of drug-induced edema in the US (ACE inhibitor-induced angioedema - UpToDate). It was likely not related to the radiotherapy.

Angioedema may occur at any time during treatment with ACE inhibitors and may even continue after the medication is discontinued. While there is no direct evidence that radiation therapy alone triggers angioedema in patients taking ACE inhibitors, if the radiation therapy affects the tissue where an...