Have you changed your steroid pre-medication regimens when treating with chemo-immunotherapy combinations for metastatic NSCLC vs chemotherapy alone?

Retrospective studies (PMID: 29935305, PMID: 30125216) have shown a correlation between poorer outcome and baseline steroid use in patients treated with single agent immunotherapy and >10 mg prednisone or equivalent, however KN189 and KN407 allowed pre-medication regimens according to local guidelines.

Answer from: Medical Oncologist at Academic Institution

I have not changed the recommended premedications for chemotherapy when giving chemotherapy combined with checkpoint inhibitors as the trials did not do this. Also there does not seem to be a difference between nab-paclitaxel and taxol in trials in squamous cancers.

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Medical Oncologist at Fox Chase Cancer Center
I agree, I have not changed my practice regarding ...

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Have you changed your steroid pre-medication regimens when treating with chemo-immunotherapy combinations for metastatic NSCLC vs chemotherapy alone?

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