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Topics:
Internal Medicine • Rheumatology • IgG4-Related Disease • Gastroenterology • Pancreatic Disorders • General Gastroenterology
How do you approach a patient with IgG4-related disease who has failed rituximab and mycophenolate and continues to rely on high-dose steroids?
The case I am considering involves a patient with biopsy-proven fibrosing dacryoadenitis.
Answer from: at Academic Institution
Most cases of IgG4-RD respond to rituximab similar to the steroid treatment. When there is a lack of response to moderate dose steroid or rituximab, either the diagnosis is not IgG4-RD or the manifestation is not due to active IgG4-RD. In many cases, if treatment is delayed, fibrosis takes over the ...
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