How do you approach a SCC of unknown primary that is metastatic to a submental (level IA) lymph node?  

I would approach both p16 positive and negative cancers the same way for a level IA lymph node. After complete workup including PET/ CT and directed biopsies, if the patient is truly diagnosed as a unknown primary squamous cell ca, I would recommend a neck dissection. If the patient has had a good ...