How do you approach choice of systemic chemotherapy for a young and otherwise healthy patient with HER2 negative esophogeal adenocarcinoma?

NCCN puts "preferred" regimens but only category 1 is cisplatin and fluoropyrimidine. When would you use that regimen over FOLFOX?

Answer from: Medical Oncologist at Academic Institution

I really think that, in the US context, FOLFOX is the standard and preferred regimen. It is now the accepted regimen in US single-arm and randomized studies. Although there are differing toxicities, I would argue that cisplatin 60-80 mg/m2 (which is the dose in published regimens) represents cruel a...

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How do you approach choice of systemic chemotherapy for a young and otherwise healthy patient with HER2 negative esophogeal adenocarcinoma?

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