How do you approach patients with positive LRP4 antibodies without clinical findings of myasthenia gravis?  

This is an interesting question. Another interesting one is what was the ordering physician looking for when they ordered LRP4. Myasthenia gravis is a clinical diagnosis. As a neuro-ophthalmologist, I see a high volume of both ocular and generalized myasthenia. I personally do not base my diagnosis ...

LRP4 antibodies can be seen in other conditions, namely amyotrophic lateral sclerosis (PMID: 27756107)  (although I should state explicitly that checking LRP4 is not in my routine/typical diagnostic plan for ALS). With that said, I agree with Dr. Subei’s assessment that the clinical ...