How do you approach the re-challenge with trastuzumab in metastatic HER2+ patients who develop cardiomyopathy on trastuzumab/pertuzumab with subsequent improvement with discontinuation?

Do you repeat the loading dose of trastuzumab?

Answer from: Medical Oncologist at Academic Institution

First, I send all my patients in this situation to the cardiologist. Second, I will re-start the treatment with close cardiology follow-up. Whether to re-load or not is an open question. I personally do not re-load, but I don’t think is wrong to re-load.

Comments

Medical Oncologist at Lehigh Valley Physicians Group
Agree. I am part of the cardio-oncology at our can...

Medical Oncologist at PPG - Oncology
What is the latest you would restart? PI says perm...

Medical Oncologist at Icahn School of Medicine at Mount Sinai
I would

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How do you approach the re-challenge with trastuzumab in metastatic HER2+ patients who develop cardiomyopathy on trastuzumab/pertuzumab with subsequent improvement with discontinuation?

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