How do you approach the workup and initial treatment of systemic AL amyloidosis?

Once a tissue biopsy has confirmed light chain amyloid, what additional tests do you perform as part of a standard workup?

In whom should treatment be initiated at diagnosis? Is systemic therapy always the preference, or can local modalities (eg. RT) be considered?

Answer from: Medical Oncologist at Academic Institution

1: Ensure that this is light chain. Mass spectroscopy of the tissue to identify/confirm is very important. Even if a patient has positive serum monoclonal protein or light chain, it does not indicate that this is light chain amyloidosis. I have had patients with MGUS and smoldering myeloma with ATTR...

Please select the option that best describes you:

How do you approach the workup and initial treatment of systemic AL amyloidosis?

Related Questions