How do you approach treatment in a patient with a solitary plasmacytoma with minimal marrow involvement (< 10% clonal plasma cells)?

Is there any data justifying the use of systemic therapy over localized therapy (e.g. radiation or surgery) in this situation prior to a progression event?

Answer from: Medical Oncologist at Academic Institution

Solitary plasmacytoma with minimal bone marrow involvement is a confusing entity as even the name seems somewhat contradictory--it is indicating there is a solitary lesion but at the same time indicating that there is systemic involvement (i.e., bone marrow involvement by clonal plasma cells). It is...

Answer from: at Community Practice

Agree with @Sarah A. Holstein's detailed and helpful explanation above. Use of advanced imaging techniques, if not done initially, and repeat biopsy for patchy disease should be considered.Our practice is to do whole-body PET CT scans for initial staging (no low-dose whole-body CT protocol available...

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Medical Oncologist at Gerard J Ventura MD, FACP
I recall @Bart Barlogie stated once (either formal...

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How do you approach treatment in a patient with a solitary plasmacytoma with minimal marrow involvement (< 10% clonal plasma cells)?

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