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How do you dose midostaurin in patients with AML who need azole antifungal prophylaxis?
FDA package insert lists posaconazole as strong cyp3A4 inhibitor and states to consider other therapies.
Answer from: Medical Oncologist at Academic Institution
Patients with acute myeloid leukemia are often neutropenic due to the disease or treatment. Anti fungal prophylaxis is often required. The azoles are attractive oral agents. However, they are Cyp3A4 inhibitors. Therefore, for patients taking Midostaurin we use micafungin for anti fungal prophylaxis....
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