How do you factor time from past cytotoxic chemotherapy exposure into diagnosing therapy-related AML?

Many patients have had prior chemotherapy exposure with newly diagnosed AML that may not have classic therapy-related cytogenetics. How do you approach this scenario?

Answer from: Medical Oncologist at Community Practice

The WHO criteria do not specify a defined time criteria for the diagnosis of therapy-related AML. WHO writes, "Most cases of t-AML present within 10 years of the most recent exposure, and the origin of AML in cases with very long latent periods may be unrelated to therapy." But even if a patient pre...

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Medical Oncologist at Conway Regional Health System
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How do you factor time from past cytotoxic chemotherapy exposure into diagnosing therapy-related AML?

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