How do you manage HER2+ metastatic esophageal cancer in frail and elderly patients?   

A standard, intensive approach to management of metastatic, HER2+ esophageal cancer would be with FOLFOX-trastuzumab-pembrolizumab, based on the KEYNOTE-811 study and subsequent FDA approval. How to adapt this to a frail, elderly patient depends on the degree of frailty, and the approach will not be...