How do you manage ovarian suppression for premenopausal patients with HR+/HER2 positive breast cancer?  

Oophorectomy and GnRH agonist are two options for ovarian suppressive therapy. There are two fundamental differences between these options. First, GnRH monthly, and especially the 3-month depot preparations, will incompletely suppress estradiol levels in some women. 17% to 25% of women on monthly Gn...