How do you proceed with radiation planning for preliminary suspected high grade gliomas after surgery when there is a delay in final molecular diagnosis?

With molecular diagnosis taking several weeks to return for some institutions, how do you handle variations in dosing and contouring between different possible suspected "high grade gliomas"? Would you go ahead and plan and treat as GBM and later adjust plan, or wait for final diagnosis before completing planning?

Answer from: Radiation Oncologist at Academic Institution

While traditionally, for glioblastoma, we start post-operative radiation therapy within 4 weeks of surgery, recent reports (for example, from Israel) have shown better survival if radiation is started at 6 weeks, which should be sufficient time for molecular studies. If for whatever reason radiation...

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How do you proceed with radiation planning for preliminary suspected high grade gliomas after surgery when there is a delay in final molecular diagnosis?

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