How do you treat HER2-equivocal breast cancer in the neoadjuvant setting?  

If there is no response to AC alone, and the Her2 is equivocal, I would treat with an anti-Her2 regimen such as THP. One could also simply give traztuzumab (possibly with pertuzumab, given the new data from APHINITY to be presented at ASCO 2017) for a year after surgery similar to the HERA trial des...