How do you treat MAS in patients with systemic JIA or AOSD with HLA-DRB1*15 alleles (given risk for DRESS hypersensitivity to IL1 or IL6 inhibitor therapy, is use of Anakinra contraindicated)?  

Tough question. HLA-DRB1*15 is pretty common, and it may be a risk allele for lung disease. I, and many others, are not convinced, however, the lung disease represents DRESS, nor that a range of biologics are the etiology of the lung disease. One of my most recent sJIA patients presented with high e...