Do you recommend genetic screening for FMF in asymptomatic first-degree relatives with a strong family history (multiple family members, severe/refractory disease)?  

In the absence of FMF symptoms, it is not necessary to obtain genetics in first-degree relatives of patients with FMF. More critical than genetics is to screen for systemic inflammation and amyloidosis, which I would consider doing. I would check inflammatory markers and urinalysis with urine protei...