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Topics:
Internal Medicine • Rheumatology • Osteoporosis • General Rheumatology • Endocrinology • Bone and Calcium Disorders
During treatment of severe osteoporosis, with PTH analogs (abaloparatide or) would rise in alkaline phosphatase level > 200 (in setting of normal GGT) warrant discontinuation of medication?
Concern for elevation in alkaline phosphatase as a precursor for bone pathology, such as increase in risk of bone malignancy potentially associated with PTH analogues.