How do you treat metastatic large cell neuroendocrine carcinoma of prostate with undetectable PSA, who had the treatment related transformation while on ADT monotherapy?

Treatment-emergent (or extra-pulmonary) high-grade neuroendocrine carcinoma (sometimes labeled HG-NEC or EP-NEC) is an increasingly seen phenomenon with the more widespread use of ARSI in the first-line setting. This is a distinct entity from prostate adenocarcinoma with neuroendocrine differentiati...