How do you treat muscle-invasive and metastatic sarcomatoid bladder cancer?

Is there a role for neoadjuvant cisplatin-based chemotherapy?

Do patients with sarcomatoid histology respond to checkpoint inhibitors?

Answer from: Medical Oncologist at Academic Institution

This is a very challenging disease with poor prognosis and low response rate to therapy. If it's predominant or pure sarcomatoid, we are opening a neoadjuvant clinical trial with dose dense MVAC plus pembrolizumab before surgery. If there is no trial, I would do upfront radical cystectomy and PLND f...

Comments

Medical Oncologist at Michigan State University
For locally advanced disease (i.e., clinically T3 ...

Medical Oncologist at University of Washington School of Medicine
Probably not pre-op chemoRT. Outside clinical tria...

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How do you treat muscle-invasive and metastatic sarcomatoid bladder cancer?

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