Would you give immunotherapy after neoadjuvant gem-cis for bladder cancer if cystectomy is being postponed for months due to non-autoimmune/unrelated comorbidities?   

If I’m understanding the question correctly, a patient is not having cystectomy due to comorbidity. I think more information would be helpful, but in general, radical cystectomy is not the only option for these patients. It’s important to remember that TMT is a category 1 NCCN recommenda...

Delay in cystectomy regardless of the use of neoadjuvant chemotherapy is associated with compromised survival outcomes (Chu et al., PMID 30840335) and if a patient receives neoadjuvant chemotherapy and is unable to undergo cystectomy for months due to comorbidities, there is no clear data to support...