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How do you treat primary retroperitoneal choriocarcinoma with liver and lung metastases and markedly elevated B-HCG?
If no testicular mass on exam or ultrasound - is there a role for orchiectomy? What chemotherapy regimen would you use and how many cycles?
Answer from: Medical Oncologist at Community Practice
Primary retroperitoneal choriocarcinoma is uncommon. The patient is IGCCC poor risk by several criteria. I strongly favor such patients be managed in high volume centers. There are a number of nuances that make this significantly more complex than good/intermediate disease before, during and after c...
Answer from: Medical Oncologist at Academic Institution
I fully agree with @Lawrence H. Einhorn's response. In patients with choriocarcinoma and markedly elevated HCG, there may also be a risk of CNS disease, as well as a risk of "choriocarcinoma syndrome" (rare but important), and thus should be managed very closely especially in the first cycle.
BHCG dropped from over 500k to 5k after 1 cycle of...
As outlined in the JCO Zon paper, HCG decline is n...
Patient had 4 cycles of BEP, B-HCG down to 30s fro...
As Dr. @Lawrence H. Einhorn says, I would follow t...