How does a prominent component of intraductal spread affect your management in a patient with otherwise intermediate-risk prostate cancer?  

There are no outcome studies that I am aware of that indicates that an intraductal prostate cancer alters prognosis in men receiving radiation therapy.  However, there are numerous reports that this is an "adverse feature" when looking at initial staging (men with this finding seem to be more l...

Van der Kwast and colleagues reported that biopsy intraductal carcinoma is an independent negative prognostic factor for biochemical relapse and metastasis in intermediate- and high-risk prostate cancer treated with radiotherapy (Eur J Cancer 2012; PMID: 22405699). If you are on the fence for otherw...

Check out my old article from Columbia on 50 cases of prostatic duct carcinoma treated with primary xrt , in Cancer in the late 70s and for which I presented the data at Astro that year.gene kopelson md