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Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • UCLA • Neoadjuvant chemotherapy • Her2+ • NCI-CCC Breast Tumor Board Question
How does clinical intramammary lymph node involvement in HER2+ breast cancer affect your neoadjuvant chemotherapy choice?
Would you prefer TCHP over TCH? Would you consider adding an anthracycline?
Answer from: Medical Oncologist at Academic Institution
The AJCC 8th edition classifies an intramammary node as an axillary node (1). Intramammary nodes are associated with axillary involvement although their independent contribution to recurrence risk remains controversial. Accordingly, I would recommend neoadjuvant TCHP in this case (I drop carboplatin...
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