How does presence of MMR deficiency/Lynch syndrome affect your recommendation on peri-operative chemotherapy for high-grade upper tract urothelial cancer?  

The presence of MMR deficiency does not really alter my recommendation regarding peri-op chemo for high-grade upper tract UC. Firstly, I don't personally think the MMR deficiency data are ready for prime-time use in chemo-prescribing; I do think this connotes for a higher likelihood of resistance, b...