For an older patient with hormone-sensitive high-volume, high-risk prostate cancer with metastases to bone who developed toxicity with enzalutamide, what other oral AR blocker would you offer?  

There are two other options that this patient might tolerate. One option is darolutamide, which has similar AR-blocking activity but does not cross the blood brain barrier. In large trials, the symptom profile was less severe than those of enzalutamide or apalutamide though some patients will have s...