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How long after high-dose IV methothrexate for chemo-refractory CNS lymphoma do you wait before giving brain radiation?
If they are symptomatic do you relax that time interval? Do you ever consider partial brain radiation instead of whole brain to minimize neurotoxicity?
Answer from: Radiation Oncologist at Academic Institution
As was taught by my mentor- "As long as possible!". Of course, the prognosis is extremely poor if the patient is chemo-refractory to IV MTX and longer-term risks of WBRT may be less relevant than present-day symptoms requiring palliation. While I do recommend WBRT, as what is visualized on MRI is ju...
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