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Hematologic Malignancies • Radiation Oncology • Pediatric Hematology/Oncology • Hodgkin Lymphoma • Internal Medicine • Hematology • Pediatric Oncology
For patients with Stage IIIB or IV HD flowing Bv-AVEPC with initial large mediastinal adenopathy, how can we avoid ISRT?
Per the NCCN guideline for HR HD, if treated per OEPA-COPDAC, you can omit ISRT. This patient received treatment per AHOD1331, which recommends ISRT for large mediastinal adenopathy.
Answer from: at Community Practice
It is true that on the clinical trial AHOD1331, patients who presented with large mediastinal adenopathy received radiation therapy as did patients who were slow early responders (Deauville 4 or 5 after two cycles of therapy). It is noteworthy that 3-year event-free survival was extremely high for a...
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Answer from: at Community Practice
Excellent question.Dr. @Harker-Murray's answer above is informative particularly the remarkable rates of radiation with N-AVD of 0.4%, while maintaining excellent outcomes. That is a preferred approach compared to what I will say next. The only addition I have: I had a patient with stage IIB wi...