Under what circumstances would you consider omitting radiation in patients with early stage, unfavorable (bulky) Hodgkin Lymphoma?   

We should first acknowledge that combined modality therapy improves progression-free survival in early-stage HL compared with chemotherapy alone. Stated more succinctly- if you give combined modality therapy, there is a lower risk of relapse; if you give chemotherapy alone, there is a higher risk of...

Prof. @Kelsey is completely correct. Thank you for the thorough answer!Omission of RT is also safe when reaching CR following 2x BEACOPPesc + 2x ABVD as shown in HD17.Borchmann et al., PMID 33539742